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Recent Activity. Search life-sciences literature Over 39 million articles, preprints and more Search Advanced search. Abdool Gaffar MS ,. Seedat YK ,. Coovadia YM ,. Khan Q Search articles by 'Khan Q'. A fifteen years old boy was admitted with two weeks histoiy of continuous high grade fever alongwith dry cough, haemoptysis and epistaxis which started on fourth day of illness.
On examination he was toxic and pale. Rest of the systemic examination was normal. Blood samples were taken for complete blood picture, Widal test and blood culture. Urinalysis and stool examination were normal.
A provisional diagnosis of enteric fever was made. There was no clinical improvement after four days therapy. Blood culture yielded growth of salmonella paratyphi A resistant to Chloromyecetin, Tetracycline, Vibramycin, Cotrimoxazole and Amoxycillin but sensitive to Ofloxacin and Ciprofloxacin. On twenty-fourth day of illness the patient developed malena and multiple petechial haemorrhages into the skin and oral mucosa. He was still febrile. Haemoglobin at this stap was 5.
Total leukocyte count dropped to 2. This picture was suggestive of pancytopenia. He was transfused one unit of whole blood and two units of packed red blood cells.
Patient had not taken any medicines before hospitalization. On twenty eighth day of illness, the fever started settling and haemoglobin came upto 8.
Total leukocyte count stepped up to 4. They immobilized the bacterium with laser tweezers in close proximity to a neutrophil held by a tiny glass pipette. A close encounter with S. Typhimurium provokes an obvious response by the neutrophil: the initially round immune cell bulges out towards the bacterium, getting ready to make contact and ingest the intruder.
Proximity to S. Typhi , in contrast, stimulates no visible changes. This differential response depends on a "natural" immune response environment, that is, on the presence of human blood serum.
To get at the signals revealing the presence of S. Typhimurium -- which are somehow absent in or obstructed by the presence of S. Typhi -- the researchers used a second experimental set up.
In a so-called Boyden chamber, either bacteria or chemicals that attract neutrophils are concentrated in a bottom compartment that is filled with human blood serum.
Neutrophils are initially concentrated in the upper compartment, and their migration to the bottom is quantified. As expected, the presence of S. Akhtar S, et al. Hematological changes in malaria: a comparative study. Article Google Scholar.
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Sci J Microbiol. Kwenti TE, et al. Identification of the plasmodium species in clinical samples from children residing in five epidemiological strata of malaria in Cameroon. Trop Med Health. Andualem G, et al. A comparative study of Widal test with blood culture in the diagnosis of typhoid fever in febrile patients. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Hoffbrand AV, et al. Postgraduate hematology.
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